GP000045: MUC1(126-149-Cys)-STn(131,144)

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Description

GP000045: MUC1(126-149-Cys)-STn(131,144)C136H214N34O59S 3301. 41 Synthetic glycopeptide. Glycosylated Mucin 1 (MUC1) peptide fragment containing amino acid sequence Pro126Gly149 (24 AA in length) from the tandem repeat (TR) region of the MUC1 protein. Tumour associated cancer antigen, sialyl Tn (STn) antigen, O glycosylation (NeuAc2 6GalNAc) at Thr131 and Thr144. The C terminus Cysteine (thiol) allows for conjugation to maleimide functionalized carrier proteins. MUC1(126 149 Cys)

C16H22O12 / 406

This process is catalyzed by a group of enzymes known as sialyltransferases

77 / / Vitamin E-d9 Acetate (rac) / α-Tocopherol-d9 Acetate

The installed glycan is the T antigen / core 1 structure (Galβ1-3GalNAcα-O-Ser/Thr)

93 / An Fmoc-protected L-threonine building block carrying a GlcNAcβ1-3GalNAcα disaccharide

C44H52N2O21 / 944

/ MUC1(126-149)-Tn(144) / Mucin1

/ MUC1(126-149)-Tn(130

C-terminal methyl ester L-threonine glycoamino acid carrying a Galβ1-3GalNAcα disaccharide (T antigen)

virulence-associated glycosylation

the sialylation of therapeutic proteins can affect their serum half-life

25-Hydroxycholecalciferol-d6